刘晓健: 女，理学博士，教授，suncitygroup太阳集团是什么导师。山西省“三晋英才”青年优秀人才（2018年）；山西省优秀硕士学位论文指导教师，山西省优秀导师团队成员。中国昆虫学会第十届理事会青年工作委员会委员；山西昆虫学会第六届理事会理事。

研究方向：

昆虫蜕皮发育的调控机理；昆虫取食行为的分子机制；害虫防治新靶标挖掘。

研究生招生：

博士研究生招生：071002 动物学

硕士研究生招生：071002 动物学（学术学位）、095132 资源利用与植物保护（专业学位）

人才培养：

李娟——2022年度山西省优秀硕士学位论文

李瑶，高雅——2024年度山西省优秀硕士学位论文

高雅——2023年度山西省研究生教育创新项目

科研奖励：

张建珍，刘晓健，张建琴，张学尧，秦国华，马恩波. 山西省科学技术奖二等奖，重要农业害虫分子毒理学与几丁质代谢研究，2017年

张学尧，张婷婷，张敏，刘晓健，张建琴. 山西省科学技术奖二等奖，重要昆虫的杀虫剂解毒与几丁质排布机制研究，2023年

赵小明，杨青，刘卫敏，刘晓健. 山西省科学技术奖二等奖，重要农业害虫几丁质结合蛋白功能及调控机制，2025年

主持科研项目：

(1) Sec16调控飞蝗表皮几丁质合成的分子机制研究，国家自然科学面上基金，项目编号：32472549，50万元，2025.1-2028.12

(2) 飞蝗几丁质合成酶基因启动子鉴定及其转录调控，国家自然科学青年基金，项目编号：31402020，25万元，2015.1-2017.12

(3) V型ATP酶基因调控飞蝗表皮几丁质合成的分子机制，山西省科技厅面上基金，项目编号：20210302123440，9万元，2022.1-2025.1

(4) 基于转录组学的苯甲酰基脲类几丁质合成抑制剂作用机制研究，山西省教育厅高校创新项目，项目编号：2016113，3万元，2016.5-2018.4

(5) 基于RNAi和转录组学阐明飞蝗蜕皮激素受体EcR和RXR的功能分化机制, 山西省科技厅青年基金，项目编号：201601D021120，3万元，2016.5-2018.12

发表研究论文：

(1) Xiaojian Liu*, Yining Cao, Suoli Zheng, Jie Xu and Jianzhen Zhang. Knockdown of Sec1/Munc18 (SM) family genes impairs feeding and molting in Locusta migratoria. Pest Management Science. 2026. 82(2):2009-2022.

(2) Xiaojian Liu*, Juan Li, Suoli Zheng, Xueyao Zhang, Jianzhen Zhang*. RNAi-mediated nuclear receptor HR96 gene knockdown inhibits feeding and gut development in Locusta migratoria. International Journal of Biological Macromolecules. 2025. 330(Pt 2):147943.

(3) Xiaojian Liu*, Mingzhu Ji, Jianzhen Zhang*. Sec61s and Sec62/Sec63 genes are essential for survival by regulating the gut and cuticle development in Locusta migratoria. Insects. 2025. 16(6):550.

(4) Babar Hussain Chang, Jianqin Zhang*, Xiaojian Liu*,Yangyang Liu, Yong Bi, Xiaojiao Kou, Mark Richard McNeill, Daqi Li, Jianzhen Zhang. Disruption of egg and nymph development via RNAi-mediated Glutamine: fructose-6-phosphate aminotransferase knockdown in Locusta migratoria: A promising strategy for pest management. Pesticide Biochemistry and Physiology. 2025. 214:106559.

(5) Xiaojian Liu, Mingzhu Ji, Ya Gao, Yao Li, Zhangwu Zhao, Jianzhen Zhang*. Coat protein I genes are essential for the morphogenesis of the intestinal tract in Locusta migratoria. Pesticide Biochemistry and Physiology. 2025. 208:106291

(6) Xiaojian Liu*, Xiaoyu Liang, Xuekai Shi, Jianzhen Zhang*.Vacuolar (H+)-ATPase genes are essential for cuticle and wing Development in Locusta migratoria. Genes. 2025. 16(2):145.

(7) Xiaojian Liu, Ya Gao, Yao Li, Jianzhen Zhang*. Targeting Syntaxin 1A via RNA interference inhibits feeding and midgut development in Locusta migratoria. Insect Science. 2025 32(2):385-397

(8) Xiaojian Liu, Ya Gao, Yao Li, Wakil A E, Moussian B, Jianzhen Zhang*. Syntaxin5 is essential for survival by ensuring midgut epithelial homeostsis and regulating feeding in Locusta migratoria. Pesticide Biochemistry and Physiology. 2024. 202, 105934.

(9) Xiaojian Liu, Yao Li, Ya Gao, El Wakil A, Moussian B, Jianzhen Zhang*. RNA interference-mediated silencing of coat protein II (COPII) genes affects the gut homeostasis and cuticle development in Locusta migratoria. International Journal of Biological Macromolecules. 2024 , 266(Pt 2):131137.

(10) Xiaojian Liu#, Juan Li, Yawen Sun, Xiaoyu Liang, Rui Zhang, Xiaoming Zhao, Min Zhang* and Jianzhen Zhang*. A nuclear receptor HR4 is essential for the formation of epidermal cuticle in the migratory locust, Locusta migratoria. Insect Biochemistry and Molecular Biology. 2022. 143:103740.

(11) Xiaojian Liu#, Xiaoyu Liang#, Jun Guo, Xuekai, Shi, Hans Merzendorfer, Kun Yan Zhu*, Jianzhen Zhang,*. V-ATPase subunit a is required for survival and midgut development of Locusta migratoria. Insect Molecular Biology. 2022. 31(1):60-72.

(12) Xiaojian Liu#, Jun Guo#, Xiaoyu Liang, Xueyao Zhang, Tingting Zhang, Weimin Liu, Jianzhen Zhang, Min Zhang*. Silencing of transcription factor E93 inhibits adult morphogenesis and disrupts cuticle, wing and ovary development in Locusta migratoria. Insect science. 2022. 29(2):333-343

(13) Xiaojian Liu#, Zheng Zhang#, Min Zhang, Xiaoming Zhao, Weimin Liu, Jianzhen Zhang,*. A ras-related nuclear protein Ran participates in the 20E signaling pathway and is essential for the growth and development of Locusta migratoria. Pesticide Biochemistry and Physiology. 2021. 178：104945

(14) Xiaojian Liu#, Anastasia M.W. Cooper#, Zhitao Yu , Kristopher Silver, Jianzhen Zhang*, Kun Yan Zhu*. Progress and prospects of arthropod chitin pathways and structures as targets for pest management. Pesticide Biochemistry and Physiology. 2019. 161: 33-46

(15) Xiaojian Liu#, Anastasia M.W. Cooper#, Jianzhen Zhang*, Kun Yan Zhu*. Biosynthesis, modifications and degradation of chitin in the formation and turnover of peritrophic matrix in insects. Journal of Insect Physiology. 2019, 114: 109-115

(16) Xiaojian Liu, Yawen Sun, Daqi Li, Sheng Li, Enbo Ma, Jianzhen Zhang*. Identification of LmUAP1 as a 20-hydroxyecdysone response gene in the chitin biosynthesis pathway from the migratory locust, Locusta migratoria. Insect science. 2018, 25(2):211-221.

(17) Xiaojian Liu#, Feng Li#, Daqi Li, Wenqing Zhang, Enbo Ma, Kunyan Zhu*, Jianzhen Zhang*. Molecular and Functional Analysis of UDP- N-Acetylglucosamine Pyrophosphorylases from the Migratory Locust, Locusta migratoria. PLoS ONE. 2013, e71970.

(18) Xiaojian Liu, Huanhuan Zhang, Sheng Li, Kunyan Zhu, Enbo Ma*, Jianzhen Zhang*. Characterization of a midgut-specific chitin synthase gene (LmCHS2) responsiblefor biosynthesis of chitin of peritrophic matrix in Locusta migratoria. Insect Biochemistry and Molecular Biology. 2012, 42: 902-910.

(19) Jianzhen Zhang#*, Xiaojian Liu#, Jianqin Zhang, Daqi Li, Yi Sun, Yaping Guo, Enbo Ma, Kunyan Zhu. Silencing of two alternative splicing-derived mRNA variants of chitin synthase 1 gene by RNAi is lethal to the oriental migratory locust Locusta migratoria manilensis (Meyen). Insect Biochemistry and Molecular Biology. 2010, 40: 824-833.

参编著作：

(1) Xiaojian Liu, Jianzhen Zhang, Kunyan Zhu. “Targeting chitin-containing organisms”-Chapter 9 “Chitin in Arthropods: Biosynthesis, Modification, and Metabolism”.Adv Exp Med Biol. 2019;1142:169-207.

(2) 张建珍，刘晓健. 《RNA干扰从基因功能到生物农药》-第2章“RNA干扰的分子机制”，科学出版社，2021.

(3) 刘晓健等. 《昆虫表皮发育与害虫防治》-第2章“昆虫表皮几丁质代谢”和第7章“以表皮代谢为靶标的化学防治策略”，科学出版社，2024.

授权专利:

(1) 刘晓健，张建珍. 膜蛋白Sec63基因及其dsRNA在害虫防治中的应用.2025.11.18, 中国, 专利号：ZL202510263732.8

(2) 刘晓健，梁晓宇，史学凯，张建珍. 飞蝗V-ATPase-V1结构域及其dsRNA在害虫防治中的应用. 2022.01.28, 中国, 专利号：ZL202010249056.6

(3) 刘晓健, 孙亚文，张学尧，张建珍，马恩波. HR4基因及其dsRNA在害虫防治中的应用. 2022.05.27, 中国, 专利号：ZL201811592139.4

(4) 刘晓健, 郭俊，张学尧，张建珍，马恩波. E75基因及其dsRNA在害虫防治中的应用. 2022.05.27, 中国, 专利号：ZL201910464696.6

(5) 刘晓健, 张政，张学尧，张建珍，马恩波. Ran基因及其dsRNA在害虫防治中的应用. 2021.07.27, 中国, 专利号：ZL201811563907.3

(6) 刘晓健, 郭俊，张学尧，张建珍，马恩波. E93基因及其dsRNA在害虫防治中的应用. 2021.07.27, 中国, 专利号：ZL201811563925.1

(7) 刘晓健, 张建珍，杨美玲，马恩波，郭亚平. 一种昆虫几丁质合成酶1B基因片段及其dsRNA和应用. 2012.01.11, 中国, 专利号：ZL201010163634.0

(8) 刘晓健，张学尧. 一种飞蝗孵化箱, 2020-11-6, 中国, 专利号：ZL201922430853.X.

联系方式:

Email: xiaojianliu@sxu.edu.cn